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How cannabis fights cancer
Often wonder whats the best way to explain to your friends the true marvelous potential of the cannabis plant, and find yourself stuck in thought trying to remember and repeat what that Dr. on Youtube said about the endocannabinoid system? It all sounded so easy to follow and you just knew you were going to remember all that wonderful data to then nonchalantly spill at a party right? Well, you likely forgot. HereÂ´s your chance to see it all in one place, organized and tidy for the eyes to follow and the mind to grasp. Soon enough you will be able to elegantly convey those deep thoughts quelled within you. You may not be an MD, but you will begin to maybe sound like one, without spouting falsehoods.
Click on the following link below for the full chart and deeper access to medical cannabis understanding.
The following is a story told and retold here on our blog, for you our readers and fans, to enjoy the words poetically stirred by a friend of the Resin Seeds family, AustraliaÂ´s famed cannabinoid healer, Mark Heinrich.
Inside the Mind of a Hash Smuggler by Mark Heinrich
It was 1978, Istanbul, Turkey. That exotic meeting point in history, where Mongols raged, and armies passed. Centuries back, it was called Constantinople.
I found myself laying on a bed in the Hotel Benson, a run down hotel not far from the bazaar, the Grand Souk. A place for smugglers of all kinds of contraband, from guns to drugs, stolen goods, and motor vehicles. It was a motor vehicle that had brought me to my current circumstance actually.
You see, I had just been released from the infamousÂ Sagmalcilar Prison. One of the most brutal and notorious prisons in the world. Staffed by sadistic guards, well versed in the ancient art of torture and torment. A place for punishment, not rehabilitation.
I had been caught smuggling cars into Iran. My home was a dungeon prison cell. There was no light. There was no humanity. There was no God.
As I was laying on my bed, having cleaned myself up and gotten rid of the lice and fleas, my employer, Zulphi, came to me and expressed his displeasure that I had been caught, and not reached Tehran with the Mercedes as contracted. I would not be paid my fee for the trip.
Instead of being paid, my boss told me that if I took a half kilo of hash to Munich, I could keep half on arrival. This is 4 days after being released from prison. My mind was shattered. I dug deep and knew I had to escape.
I thought to myself, â€śRight you c**t, Iâ€™m going to fly instead to Zurich, and keep the lot for myself!â€ť They had betrayed me and I had suffered. I wanted out at any cost, but I wanted payback as well.
Next day, Zulphi brought the half kilo of absolute premium un-pressed Turkish hash. I packed it into the pocket of an old Greyhound inflatable pillow that I had with me. I just ziplocked it shut and slid it into the map pocket of my Jansport backpack. This particular model had the map pocket, not on the outside of the pack, but rather between my shoulders and the pack. Effectively so that when going through customs, I would be taking my pack off for inspection if asked, and would lay it down with the frame bottom most, out of sight. It was very difficult to tell a flap was there.
I felt no fear. I felt nothing actually. My mind was still shattered, and I was in no fit mental state to be making good life choices.
I arrived at the airport. Zulphi drove. Checking in, I went ahead and booked my ticket, using credit I had on a miscellaneous charges order from Pan Am. Very softly though, in an act of brinkmanship, I asked to be booked on the flight to Zurich I noticed was leaving within 5 minutes of the flight to Munich.
My drug smuggling career was launched.
As soon as I had my ticket, I was asked to hurry to the departure lounge as my flight was on last call and I was the last to board. I literally ran to the gate, past a Turkish policeman. Just as I was nearly on the tarmac, the cop hollers â€śStop!â€ť. I turn, still no fear, and see him holding my boarding pass. I had dropped it in my haste. I thanked him and shook his hand and gave him my last pack of Marlboros. He told me to hurry cos the plane was waiting on me.
Takeoff, then on the way to Zurich. I recall the Alps in the sun. I pondered the airport and chuckled. Zulphi had always told us the Turkish Feds were****knuckles, and that money or baksheesh always gave you a higher rank than them. I felt supremely confident. The hash was in my bag and I was watching the hostesses ass. Oh my I recall that ass. It was the first female ass I had seen in months. Oh gosh I loved that woman.
In Zurich, I picked up my pack, and headed out through to customs. I was very placid at the time, enjoying my freedom, feeling no fear or anxiety.Â I pulled out a smoke, grabbed a tourist map, and just walked through the green corridor â€śNothing to Declareâ€ť, right past the customs officer. I then stopped and turned and asked him for a light up your smoke. Then off.
Straight to the ticket counter to book a connecting flight to London. I had decided to return to Montreal, via London (to sell some hash -I was broke you see) and New York.
Liftoff from Zurich on Swissair. Oh my golly gosh, but another wonderful air hostessâ€™ ass. The Swiss I find are a little perter than the Pan Am ass. lol.
The sun is on my face. Iâ€™m reading and relaxing. Confident the hash will still be there in London. Then, my world fell apart. I read an article on the baggage handlers at Heathrow. They were referring to it as â€śThief-rowâ€ť. I was instantly panicking. I was fearful that some crummy pommy baggage handler would steal my hash and spoil my day. I could not have that.
I still had no fear or anxiety about the hash. I think being new to hash and never having smoked weed, let alone hash, it meant nothing to me. So it just sat in my pack, no different than as if it were my sleeping bag. I recall thinking about the hash for the first time. It had a funny sweet smell, looked and felt and moved just like fresh brown sugar. I was a naive.
Landing in London. It is pissing down rain. I hate England. My previous experience was that it was cold, wet and expensive. And I was pissed at the Poms. This bloke had called me a â€śWogâ€ť in a London pub one night, and told me to **** off back to Australia. Guys, I am a blond haired Caucasian, not European looking. Makes me laugh about it now after all these years.
We raced down the stairs from the plane and across the tarmac, waiting and watching as our bags were checked over by a sniffer dog. I saw my pack on the last of 5 trolleys. Just as the dog neared the last trolley and my bag, the heavens really opened, and the handler and dog retreated out of the rain. My bag was not checked.
This time I felt a tinge of anxiety, but still no fear. I was still so happy and supremely in control. I had no fear of authority. I saw it as a mental challenge, a game of sorts. I was good at it. Zuphi had taught me well.
I might toss in here that I was flying on one of 3 passports I had. All in my name, all legit. Only one was valid though. I had reported the other 2 stolen and gotten replacements. These 2 had both been altered by the smuggling syndicate, and had doctored stamps and visas, and other customs stamps removed completely.
In London, I head to the Youth Hostel for some much needed rest. The hash was still all there, still just sitting in a ziplock bag inside the map pocket. All half kilo of it.
I sold 2 ounces straight away. I could not believe how eager people were to buy some of my brown sugar.
Then a major problem. All air traffic controllers were on strike, and no flights were leaving for North America, except for those of one airline. Laker Airlines was my saviour. Sir Freddy Laker and the first international budget airline ever. But there was a queue, and that queue went for 3 kilometers from the ticket office at Victoria Station. We worked small groups, to team up for self protection and company as the line slowly edged itâ€™s way forward. The hash still sat in my pack. I was so calm and confident, I left my pack with this small group of young hippies, and went to do my ablutions, eat and just stretch. Sleeping on the pavement with drizzly weather for 3 days was no fun, but looking back it was a blast. The whole dynamic of this conga line of hippies, all returning to the US for school in the fall. And only one airline and only 2 flights a day.
In the air with Laker Airlines. my pack and the hash still safely aboard. Next stop, La Guardia Airport and US customs. I had worked out in my mind a strategy to enter through New York, and then catch a Greyhound bus to Montreal. My final destination.
I debark and head to get my pack. Then on to immigration and customs. My US visa is genuine and valid. I feel supremely confident. The horrors of Sagmalicar were fading. Joy was again pervading my mind. My health was improving.
Up to Customs I go after getting my visa stamped. This time no green gate. Everyone must present bags. Still no fear. Absolute control.
The customs officer asks me where I was going. I told him I was off to Montreal, then on to Edmonton in Canada for the Commonwealth Games. The customs agent wished me well, and helped me to lift my pack onto my back. I must say I was ever so thankful lol.
Out of the airport I head, to the taxi rank. Now I am starting to get excited. I can see the end, My goal. The Montreal Youth Hostel â€“ a place I knew well. A place to recuperate. A place to sell my hash.
Driving up through Vermont. I recall the beautiful colours of autumn. I was nearly there. Mounting excitement.
The Canadian border at last. I go into the immigration office as I have to show my passport. It takes some time as I have to wait on the immigration officer to return from a break. I am the only international passenger on the bus. All the others are re-boarded and their luggage re-stowed. You see, at the border, you have to unload your bag and identify it to customs.
A half an hour passes. I am starting to panic inside. I feel fear for the first time, but I have the beast in control. I finally finish and walk out to the bus. There, by the bus, is my pack standing alone ready for loading, right between two customs officers and an RCMP officer. I just crashed inside when I saw this. The reality and magnitude of the adventures of a drug smuggler came haunting me. I thought â€śHow unfair!â€ť â€“ to have come all this way to get busted at the border.
I walked towards my pack and the bus. I put my shoulders back and put on my smugglers guise. Zulphi truly had taught me well in the arts of smuggling. It was a game. A challenge. The memories of the horrors of Sagmalicar oddly absent from my mind. An ominous portent though of what was to come in my mind 20 years on.
I picked up my pack and was unsure what was going down. Then the RCMP officer told me to shake a leg and get on the bus. I had made them late! I had ****ing made them late lol. My legs pumped up the stairs and I sat into my seat. That short ride to the terminus from the border was and is the most special bus ride I have ever taken in my life.
I trudged up the stairs to the Youth Hostel in Aylmer Street, and for the first time in nearly 5 months, I felt safe. I felt no fear. I had been paid in full for my epic car smuggling run from Munich to Tehran.
One of the most difficult parts of the job is receiving emails from countless people around the world wanting information or seeds with the hopes of providing themselves or loved ones with an often illegal and frowned upon solution. While we are not ourselves physicians here at Resin Seeds, we do however collaborate with MD’s around the world who have taken upon themselves to end the stigma surrounding cannabis and help their patients feed their endocannabinoid system and put them on a path to healing. One of these brilliant minds is Dr. Andrew Katelaris, from Australia.
Dr. Katelaris has over 25 years of experience with medicinal cannabis, while recently concentrating his efforts on intractable epilepsy. Despite being deregistered by the Australian medical community since 2005 for his cannabis research, he continues with his work. He has been arrested dozens of times; many might consider he sacrificed his career.Â However, he continues to fight for and support the rights of all suffering who turn to MMJ in an effort to preserve and improve their health.
The guide that follows is one he wrote with cancer patients specifically in mind. These dietary guidelines address the major schools of thought re: cancer and diet and help summarize them in a convenient easy to read format. It also will help those seeking more arms to fight cancer, as it is currently believed the best approach is to attack cancer from multiple angles of conventional and holistic therapies, as well as diet and mindset.
Dietary Guidelines for Cancer Patients
Using Cannabis Treatments
Given the complexity of the topic and the multiplicity of opinions on the subject, it is likely these will not be the last words written on the subject of diet and cancer. However, what I will attempt to do is briefly describe the major schools of thought, highlighting the strengths and weaknesses of each. Firstly, amongst knowledgeable people there is consensus that the quality of the diet is primary in the prevention of the cancer diseases and critical in their management. The Gerson, Wigmore and Budwig schools of thought all have merit. Recent developments in the understanding of human biochemistry will allow a more rational approach, tailored to individual patient needs. Cancer is a heterogeneous group of diseases having in common loss of differentiation from normal tissue and uncontrolled cell growth. Cancer results from the imbalance between oxidative stress damaging the cellular DNA and protective and reparative mechanisms which counter this.
Vibrant good health is dependent on a healthy mental attitude, fresh air and mindful breathing, adequate intake of pure water and a regular supply of vine and tree ripened fruits, berries and vegetables, supplemented with nutritional herbs, spices and judiciously selected supplements. Navigating through a maze of junk food, electromagnetic fog and a soup of toxic chemical can place extreme burden on a person’s physiology. However, with careful choices the body’s inherent defense mechanisms can ensure correct functioning.
Water: Second only to oxygen in immediate importance to survival, this key nutrient is often ignored. Caffeinated beverages and sweetened processed fruit juice drinks are no substitute for pure water. Municipal supplies are laced with chlorine and fluorine, the latter sourced as a waste product from fertiliser manufacture. PCBs in plastic bottles are also detrimental. Water may be harvested, filtered or purchased (Pureau 10 litre cask with PCB free plastic is good quality and relatively inexpensive) Extreme practitioners insist on many litres daily but between 1 and 3 litres daily, depending on body size and environment, should be adequate. Drink water even if you don’t feel too thirsty, as chronic dehydration renders us less sensitive to proper signalling.
The Alkaline diet: This diet aims to improve health by eating so-called alkaline foods and avoiding acidic ones, to restore the body’s pH balance and restore health. This approach has produced some good results because their practices are correct, even though the explanations are erroneous. The acid/alkaline balance, the pH of the body, is closely controlled by breathing and kidney function to keep the pH very close to neutral and no matter how poor the diet is the pH will not be altered, until the terminal phase of illness. Therefore, the pH altering effect of bicarbonate is rapidly neutralised by the body. Instead of seeing foods as being acidic or alkaline they should be seen as pro-oxidant or antioxidant. As it turns out all the “alkaline” foods are highly antioxidant, while the highly processed “acidic” foods cause oxidative stress. Acidic fruits like lemons and limes do not hinder but help healing because they are potent antioxidants.
Gerson therapy promotes body healing by flooding the system with vitamin, mineral and antioxidant rich juices to assist in restoring the immune system and repair mechanisms. The Wigmore school uses wheat grass for the same purpose. In advanced disease up to 200ml of wheatgrass juice daily can be taken. The wheat grass should be harvested at peak tenderness, about 10-15cm high, as the vitamin and enzyme content is at maximum. The Gerson and Wigmore methods can be beneficially combined. Fasting, especially brief fasts followed by natural raw food can be a powerful healing modality. Prolonged fasts may benefit some, but excessive starvation weakens the immune function.
The ketogenic diet may control intractable epilepsy but its role in cancer treatment is not established. Some people have experienced good results from a ketogenic diet, but this is more likely due to the elimination of harmful foods from the diet, rather than starving the cancer. Eliminating processed sugar is essential, as excess sugar sticks to cells (glycosolation) casing oxidative stress and tissue aging. However, the brain can only metabolise glucose and if none is available it will be produced in the body. It is simply not possible to starve a tumour, but one must nourish the body to achieve ideal immune function, while modestly restricting calories. Those who avoid moderate ingestion of carrot and other juices for fear of the sugar content are doing themselves a disservice.
The Budwig diet concentrates on omega 3. There are two essential fatty acids. Being essential means they cannot be made in the body but must be supplied in the diet. The essential fatty acids are omega 3 and omega 6. Put simply omega 6 is used to make chemical signals which have a pro-inflammatory action. This is necessary to ward off pathogens and assist wound healing. Omega 3 produces chemical messangers which damp down inflammation. When the intake of omega 3 and 6 is about 1:3 the system is in balance, with just enough inflammation, but appropriately damped. With omega 3 deficiency the body is in a state of chronic inflammation, with tissue damage, including damage to the DNA. Omega 3 can be modified in the body to form DHA and EPA, the form of omega 3 found in cold water fish. A healthy human can modify the plant form of omega 3 called ALA, as long as they have the necessary B group vitamins and mineral cofactors and avoid excess saturated fats. Hulled hemp seed is an ideal way to obtain omega 3 and the cofactors. Green smoothies are a convenient way to ingest hemp seed. Combining fruits and berries, hemp seed and a few green leaves in a blender makes an ideal meal substitute. Hulled hemp seed can also be added to almost any meal with benefit. They should not be cooked. Thirty to fifty grams a day is adequate. Flax oil has the highest ratio of omega 3 to omega 6. In cases where the omega 3/6 balance is very disturbed the addition of a quality flax seed oil will help lift it towards normal. Most flax seed oils on the market are seriously substandard. Stoney Creek Oils produce a quality product. Flax seed oil can be added to salads and soups, combined with lemon juice or apple cider vinegar. Garlic can provide the sulphur containing amino acids which help utilise the omega 3 and should be included in the diet.
The contamination of the oceans from plastics, mercury and radiation continues unchecked. At current trends the marine ecosystem will collapse within our lifetimes. At present, carefully selected seafood can still be safely and beneficially included in the diet, for the time being. Fish oil is a rendered product of questionable health benefit. Krill oil avoids most of the problems with fish oil. Red meat is a controversial topic. There is no doubt that cattle force fed grain in feedlots produce a very unhealthy meat. However, wild game and to a lesser extent naturally grown grass fed meat can have as much omega 3 as seafood and be a healthy component of the diet, in moderation, if desired. Vegetable soup is easy to prepare and generally highly antioxidant.
Herbs and spices are beneficial, with proven action against cancer. Tumeric, ginger, garlic, chilli and many others are beneficial. Supplements are a complex topic. Just because tumeric is a beneficial spice does not mean the capsules sold in the pharmacy have retained their activity. The same goes for many supplements Resveretrol from grape skins is a super nutrient but the powder in capsules may have lost its activity unless preserved by careful handling. It can be difficult to know which supplement has been prepared so as to preserve activity, so having things in their natural form is often best. Juice Plus is a fruit and vegetable concentrate that has been laboratory tested and proven to retain active phytonutrients. It is available via distributors. Iodine supplements are useful (see appendix) The structure of the diet is an individual affair and can vary with different seasons and stages of a person’s health. A certain amount of experimentation is necessary. One suggestion would be a hemp seed green smoothie for breakfast, vegetable juices and herb teas during the day with a raw salad, followed by a cooked meal if desired in the evening. Being overweight is detrimental to healing so a gradual but progressive weight loss by elimination of all processed food is necessary.
A few closing suggestions are in order. Lemons and limes are an ideal start to the day, squeezed into a glass of water. A mixed vegetable salad in season is an ideal meal in itself and an excellent first course to a larger meal. Eating an adequate amount of raw food before a cooked meal aids digestion significantly. Charts of ORAC (oxygen radical absorbance capacity) give an indication of the antioxidant value of the food and are a useful planning aid. Such charts are available on the internet. Bear in mind this data is indicative only, because the antioxidant effect of a food depends not only on the type of food, but its quality and state of ripeness and preservation
The body requires a certain amount of activity, so be as active as your condition will allow. Remember, cancer is a word, not a sentence. DonÂ´t be intimidated by the fear mongering and negativity used by allopathic practitioners to frighten people into toxic and dangerous therapies. Yoga practices of various forms can assist in connecting with a spiritual centre. When practices assiduously they can also awaken the natural intuition and insight needed in charting a course back to good health The medical uses of cannabis. There is abundant evidence from tisue culture and animal experiments that components of cannabis have significant activity in preventing and treating cancer. In addition, cannabis can provide very effective relief across a wide range of symptoms. Despite this evidence and a complete lack of toxicity and side effects, human studies are only just being organised. Rick Simpson oil has received much internet attention. This is a heat treated solvent extract of a high THC indica plant given at high doses with curative intent. I have limited experience with RSO but believe the internet reports are often exaggerated or even fabricated in some cases. Intolerance at the suggested doses is common. Whilst I wouldn’t discourage experimentation with cannabis oil, we are pursuing more refined preparations of cold extracted cannabis containing CBD and THCA, that is THC in its natural acidic form. The CBD and THC have a synergistic effect against cancer and the CBD moderates the psychotropic effect of THC, allowing higher, more effective doses to be used. Some are advocating juicing cannabis, but this requires growing capacity beyond most patients.
There is growing evidence that X ray and chemotherapy treatments can induce the formation of resistant cancer stem cells. Thus, while most patients will see an initial response to allopathic treatment, this treatment actually drives the cancer into generating resistant cells that produce a relapse, with metastases that become resistant to the treatments used. In the event of receiving a cancer diagnosis the first decision to be made is whether one will take responsibility for one’s own health or abrogate that responsibility and allow the pharmaceutical industry to direct treatment.. It can be a daunting prospect to untie oneself from the umbilical cord of hospital based treatments and seek healing by natural methods. This decision can be made more complicated by the multiplicity of programs and often conflicting advice on offer. There are certain cases where surgery should be considered as a first option. A bleeding bowel cancer is best excised as soon as practical, in my opinion, as this will stabilise the situation without compromising the immune system and its natural healing capacity. However, one thing appears certain. Both diet and cannabis based treatments will be more effective as a first line of action. Too often, patients will turn to these methods after their third or fourth relapse, when the chances of success are much reduced.
I hope these few comments are of value and I wish you well.
Dr Andrew Katelaris
Conducting a test , a brain child of @resinseedsofficial , who discussed placing plants out for the animals explaining that perhaps the cannabinoid profiles that attract the animals naturally may perhaps be the ones better/best suited for us naturally . Pictured is a #DieselTonic 1:1 pheno from #ResinSeeds ., put half a dozen clones in 1gal pots outside 3 months ago in a 3 ft hole . I actually forgot about them during the work flow and a week ago I stumbled upon them . The only water given was a 2 gallon container full the day I found her . She seems to have acclimated to zone 3 . She has obviously seen harsh freezing conditions and yet , she rolls along , certainly much slower than her sisters aboard the spaceships but nevertheless .., intriguing , I'm learning , and so sharing . Not much evidence of much eating to current @resinseedsofficial , a few leaves have been munched maybe 2 or 3 I see . Tracks are all around , they certainly know it's here .??. Perhaps when it grows up out beyond the hole further , we shall see more ., the chickens are loose now too ., adding them to this farmyard experiment we are …, yes ?? #GreenGoddessGardens #ResinSeeds #cbdreads #experiment
Listening to an interview with Resin SeedsÂ´ friend Dr. William Courtney, we learned that deer and other animals will occasionally encounter cannabis plants but eat only from the leaf and not from the flowering bud containing the majority of the psychoactive resin. It is thought these animals are consuming on average 30 micro-grams per session; a typical heavy cannabis user may consume up to 300,000 micro-grams in edible form. One major point to consider here is the plantÂ´s bi-phasic effect, meaning higher and higher doses of cannabinoids can induce the very effects it is known for mitigating. Is it possible that the deer and other animals, who may return to ingest the raw cannabinoids just a few times weekly, instinctively know that a lower dose will be more effective in maintaining a healthy endocannbinoid system? We may have a lot to learn in dosing, nature appears to prefer microdosing as a regular alternative. Perhaps we should consider re-evaluating our relationships with our healing plant to allow it to truly bring us its highest medicinal benefit.
Our enthused grower set-off to plant some healthy Dieseltonic cuttings along his property, which is visited by friendly deer and other animals on a regular basis. His relationship and connection to nature is truly impressive, and the animals trust him well enough to be hand fed apples and other such delights.
The idea is to have several plants, not only the 1:1 pheno of Dieseltonic, but other chemotypes and strains as well, and try to see if the deer will help us decide which plants may be better suited for general endocannabinoid maintenance. It may be a useless or crazy experiment, as we already understand a fair amount of our traditional cannabinoids and their roles in providing homeostasis.
Follow along as we update this post with pictures info and more!
A great article written by our friends at Project CBD in California, passing on the essential knowledge needed to understand the essence of cannabinoid therapy. One key reminder, is that there is no precise dose per person; that is to say, everyone’s strain and dosing requirements are unique, so there is no set dose. The following article will help you understand the complexities of dosing and why microdosing is the best place to start.
Beginner’s guide to CBD Medicine
By Project CBD on July 13, 2016
A BEGINNER’S GUIDE TO CANNABIDIOL & CANNABIS THERAPEUTICS
How to use cannabis for maximum therapeutic benefit. Most health professionals have little experience in this area. So Project CBD has created a CBD Userâ€™s Manual for patients that addresses key questions about cannabidiol and cannabis therapeutics.
What is CBD?
Cannabidiol or CBD is a non-intoxicating component of the cannabis plant with enormous therapeutic potential. Although CBD doesnâ€™t make people feel high like THC does, itâ€™s causing quite a buzz among scientists, health professionals, and medical marijuana patients who are using CBD-rich products to treat a wide range of conditions – chronic pain, cancer, Crohnâ€™s, diabetes, rheumatoid arthritis, PTSD, cardiovascular disease, anxiety, antibiotic-resistant infections, multiple sclerosis, schizophrenia, and more. Academic research centers in the United States and elsewhere are currently studying the effects of CBD on these and other ailments. Scientists refer to CBD as a â€śpromiscuousâ€ť compound because it confers therapeutic benefits in many different ways while tapping into how we function physiologically and biologically on a deep level. Extensive preclinical research and some clinical studies have shown that CBD has strong anti-oxidant, anti-inflammatory, anticonvulsant, anti-depressant, anti-psychotic, anti-tumoral, and neuroprotective qualities. Cannabidiol can change gene expression and remove beta amyloid plaque, the hallmark of Alzheimerâ€™s, from brain cells.
Which is better CBD or THC? Cannabidiol and THC (The High Causer) are the power couple of cannabis therapeutics; they work best together. CBD and THC interact synergistically to potentiate each otherâ€™s curative qualities. CBD enhances THCâ€™s painkilling and anticancer properties, while lessening THCâ€™s psychoactivity. CBD can also mitigate adverse effects caused by too much THC, such as anxiety and rapid heartbeat. When both compounds are present in sufficient amounts in the same cannabis strain or product, CBD will lower the ceiling on the THC high while prolonging its duration. (â€śRelaxing but not intoxicatingâ€ť is how one patient described CBD-rich cannabis.) CBD broadens the range of conditions treatable with cannabis, such as liver, cardiovascular and metabolic disorders, which may be less responsive to THC-dominant remedies. CBD and THC both stimulate neurogenesis, the creation of new brain cells, in adult mammals.
Whatâ€™s the best way to take CBD? The most appropriate delivery system for CBD-rich cannabis is one that provides an optimal dose for a desired duration with few unwanted side effects. CBD-rich cannabis flower varietals for smoking or vaping are available in many medical marijuana dispensaries, but most CBD patients prefer non-inhalable products made with cannabis oil concentrates. Although banned by federal law, measurable doses of potent CBD-rich cannabis remedies are available in many non-smokable forms and can be utilized in various ways. The time of onset and duration of effect vary depending on the method of administration. CBD-rich cannabis oil products can be taken sublingually, orally (as edibles, lozenges, beverages, tinctures, and gel caps), or applied topically. Concentrated cannabis oil extracts can also be heated and inhaled with a vape pen. Inhalation is good for treating acute symptoms that require immediate attention; the effects can be felt within a minute or two and typically last for a couple of hours. The effects of orally administered CBD-rich cannabis oil can last for four hours or more, but the onset of effects is much slower (30-90 minutes) than inhalation.
Can CBD cure epilepsy? Marijuana has a rich history as a medicine for quelling seizures and convulsions going back thousands of years. In the mid-19th century, the U.S. Pharmacopeia listed cannabis tincture as a treatment for pediatric epilepsy, and subsequent scientific studies have documented the anticonvulsant effects of CBD, THC, and whole plant cannabis. CBD-dominant/low- THC cannabis strains and oil extracts can facilitate dramatic improvement in some children with intractable seizure disorders. Between 10-15 percent of severe childhood epileptics who are given CBD oil products experience a near complete cessation of seizures; most improve (with a decrease but not total elimination of seizures); and some children have worse seizures when they take CBD. Many parents of epileptic children have learned through trial and error that augmenting CBD-rich oil by adding some THC — or better yet, THCA, the unheated, non-psychoactive form of THC thatâ€™s present in raw cannabis flowers and leaves — helps with seizure control. The take-home message: Low-THC cannabis oil products donâ€™t work for everyone. Patients of all ages need access to a wide spectrum of whole plant cannabis remedies, not just high CBD oil.
What is the right CBD:THC ratio for me? Cannabis therapeutics is personalized medicine. There is no single ratio or strain or product thatâ€™s right for everyone. Optimize your therapeutic use of cannabis by finding the proper combination of CBD and THC that works best for you. A personâ€™s sensitivity to THC is a key factor in determining the appropriate ratio and dosage of CBD-rich medicine. Many people enjoy the cannabis high and can consume reasonable amounts of any cannabis product without feeling too high or dysphoric. Others find THC unpleasant. CBD can lessen or neutralize the intoxicating effects of THC. So a greater ratio of CBD-to- THC means less of a high. In some states with medical marijuana laws, cannabis oil concentrates and other products with varying ratios of CBD:THC are available so users can adjust or minimize psychoactive effects to suit their needs and sensitivities. Those who donâ€™t like THC have the option of healing without the high by using a CBD-rich remedy with only a small amount of THC. But a low THC remedy, while not intoxicating, is not always the most effective treatment option. In essence, the goal is to administer consistent, measurable doses of a CBD-rich remedy that includes as much THC as a person is comfortable with.
Are specific CBD:THC ratios better for different conditions? Some patterns are beginning to emerge. For anxiety, depression, spasms, psychosis, and seizure disorders, many people report they do well starting with a small dose of a CBD-rich remedy with little THC. For cancer, autism, and many other diseases, some say they benefit more from a balanced ratio of CBD and THC. Extensive clinical trials conducted outside the United States have shown that a 1:1 CBD:THC ratio can be effective for neuropathic pain. Some people use cannabis products with different CBD:THC ratios at different times of the day (more CBD for sunlight hours, more THC at night). Almost any cannabis strain or product theoretically could benefit a wide range of autoimmune and inflammatory disorders because THC and other cannabis components activate the CB2 cannabinoid receptor, which regulates immune function. Note: The CBD:THC ratio is not an indication of how much CBD or THC is present in a given cannabis product or strain.
What is the optimal dosage of CBD? An effective dosage can range from as little as a few milligrams of CBD-enriched cannabis oil to a gram or more. Begin with a small dose of high CBD/low THC oil, especially if you have little or no experience with cannabis. Take a few small doses over the course of the day rather than one big dose. Use the same dose and ratio for several days. Observe the effects and if necessary adjust the ratio or amount. Donâ€™t overdo it. Cannabis compounds have biphasic properties, which means that low and high doses of the same substance can produce opposite effects. Small doses of cannabis tend to stimulate; large doses sedate. Too much THC, while not lethal, can amplify anxiety and mood disorders. CBD has no known adverse side effects, but an excessive amount of CBD could be less effective therapeutically than a moderate dose. â€śLess is moreâ€ť is often the case with respect to cannabis therapy.
If CBD is so good, wonâ€™t pure CBD be even better? Single-molecule CBD will inevitably become a federally approved Big Pharma medicine. Products infused with a crystalline CBD isolate, derived and extensively refined from industrial hemp, are already being marketed by unregulated internet storefronts. But single-molecule CBD is less effective therapeutically than whole plant CBD-rich oil extract. Scientific studies have established that synthetic, single-molecule CBD has a very narrow therapeutic window and requires precise, high doses for efficacy, whereas lower dose, whole-plant, CBD-rich treatment regimens are already showing efficacy for many conditions among patients in medical marijuana states. Whether synthesized in a Big Pharma lab or derived from industrial hemp, single-molecule CBD lacks critical secondary cannabinoids and other medicinal compounds found in high-resin cannabis strains. These compounds interact with CBD and THC to enhance their therapeutic benefits. Scientists call this the â€śentourage effect.â€ť Numerous cannabis compounds have medicinal attributes, but the therapeutic impact of whole plant cannabis is greater than the sum of its parts.
Is there a difference between CBD derived from hemp and CBD derived from marijuana? If you live in a state where medical marijuana is legal and available, look for CBD products made from high-resin cannabis (rather than low resin industrial hemp) that are sold in medical marijuana dispensaries. Hemp-derived CBD-infused products of varying quality are also available via dozens of internet storefronts. Compared to whole plant CBD-rich cannabis, industrial hemp is typically low in cannabinoid content. A huge amount of hemp is required to extract a small amount of CBD, thereby raising the risk of contaminants because hemp, a bioaccumulator, draws toxins from the soil. Thatâ€™s a great feature for restoring a poisoned ecosystem, but itâ€™s not recommended for extracting medicinal oil. Heavily refined CBD paste or terpene-free CBD powder is poor starter material for formulating CBD-rich oil products. The FDA has tested dozens of so-called CBD â€śhemp oilâ€ť products and found that in many cases these products contained little or no CBD. CBD-infused nutraceuticals have not been approved by the FDA as food supplements; nor are these products legal in all 50 U.S. states. By and large, however, interstate CBD commerce is tolerated by federal authorities.
Is it safe to inhale hemp CBD oil fumes from a vape pen? Many cannabis- and hemp-derived CBD vape oil products include a thinning agent, which dilutes the oil that is heated and inhaled by vape pen users. Beware of vape pen oil that contains propylene glycol. When overheated, this chemical additive produces formaldehyde, a carcinogen, as a byproduct, according to a 2015 report in the New England Journal of Medicine. Why do so many vape oil products contain this thinning agent? Itâ€™s because of the dubious quality of the extracted material from which these unregulated cannabis oil products are made.
Does CBD have any adverse side effects? What about drug interactions? CBD is a very safe substance, but patients taking other medications should check with their doctor about drug interactions, which are more likely when consuming high doses of single-molecule CBD products. At sufficient dosages, CBD will temporarily deactivate cytochrome P450 enzymes, thereby altering how we metabolize a wide range of compounds, including THC. Cytochrome P450 enzymes metabolize more than 60 percent of Big Pharma meds. CBD is a more potent inhibitor of cytochrome P450 than the grapefruit compound Bergapten, so ask your doctor if grapefruit interacts with your medication. If grapefruit does, then CBD probably does, too. Patients on a CBD-rich treatment regimen should monitor changes in blood levels of prescription medications and, if need be, adjust dosage.
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